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- Title
Molecular characterization of colorectal cancer related peritoneal metastatic disease.
- Authors
Lenos, Kristiaan J.; Bach, Sander; Ferreira Moreno, Leandro; ten Hoorn, Sanne; Sluiter, Nina R.; Bootsma, Sanne; Vieira Braga, Felipe A.; Nijman, Lisanne E.; van den Bosch, Tom; Miedema, Daniel M.; van Dijk, Erik; Ylstra, Bauke; Kulicke, Ruth; Davis, Fred P.; Stransky, Nicolas; Smolen, Gromoslaw A.; Coebergh van den Braak, Robert R. J.; IJzermans, Jan N. M.; Martens, John W. M.; Hallam, Sally
- Abstract
A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity. Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct molecular subtype.
- Subjects
COLORECTAL cancer; PERITONEAL cancer; PERITONEUM diseases; CYTOSKELETAL proteins; HYPERTHERMIC intraperitoneal chemotherapy; DISEASE progression
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-32198-z