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- Title
Adverse biobehavioral effects in infants resulting from pregnant rhesus macaques' exposure to wildfire smoke.
- Authors
Capitanio, John P.; Del Rosso, Laura A.; Gee, Nancy; Lasley, Bill L.
- Abstract
As wildfires across the world increase in number, size, and intensity, exposure to wildfire smoke (WFS) is a growing health problem. To date, however, little is known for any species on what might be the behavioral or physiological consequences of prenatal exposure to WFS. Here we show that infant rhesus monkeys exposed to WFS in the first third of gestation (n = 52) from the Camp Fire (California, November, 2018) show greater inflammation, blunted cortisol, more passive behavior, and memory impairment compared to animals conceived after smoke had dissipated (n = 37). Parallel analyses, performed on a historical control cohort (n = 2490), did not support the alternative hypothesis that conception timing alone could explain the results. We conclude that WFS may have a teratogenic effect on the developing fetus and speculate on mechanisms by which WFS might affect neural development. Little is known about the consequences of prenatal exposure to wildfire smoke on biobehavioural outcomes. Here, the authors show that infant rhesus monkeys exposed early in gestation to wildfire smoke from the 2018 Camp Fire in California show more inflammation, blunted cortisol and altered behaviour outcomes compared to non-exposed animals.
- Subjects
CALIFORNIA; RHESUS monkeys; SMOKE; MACAQUES; PASSIVITY (Psychology); WILDFIRES; PRENATAL exposure; INFANTS
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-29436-9