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- Title
Comparison of Creatinine, Cystatin C and Combined Creatinine-Cystatin C for Renal Function Assessment in Patients with Diabetes.
- Authors
Umar, Saba; Sabir, Sohail; Azam, Nadeem Malik; Aamir, Muhammad; Bibi, Afshan; Altaf, Ashfaq; Siddiqi, Faud Ahmed; Sabir, Haroon; Raja, Khalid Mehmood; Butt, Batool
- Abstract
Objective: To compare the estimated glomerular filtration rate (eGFR) assessed through the CKD-EPI equations based on creatinine, Cystatin C and creatinine-Cystatin C levels for estimating kidney function among patients with diabetes. Study Design: Cross-sectional analytical study. Duration and Place of Study: Nephrology Department, Armed Forces Institute of Urology, Rawalpindi Pakistan, from Aug 2020 to Mar 2021. Methodology: A total of 70 patients were recruited. Serum samples were collected for creatinine and Cystatin C levels and 24 hours of urine for creatinine clearance. The eGFR values were calculated using the creatinine, Cystatin C and combined creatinine-Cystatin C CKD-EPI equations and compared with 24 hours of urinary creatinine clearance. Results: A total of 22 (31.4%) patients had early stage, while 48 (68.6%) had late-stage chronic kidney disease (CKD). The highest Spearman correlation coefficient was found for eGFR CKD-EPIcr-cys (rho=0.844), followed by CKD-EPIcys (rho= 0.835) and CKD-EPIcr (rho=0.709). Conclusion: CKD-EPIcr-cys is the most accurate, recommended method of calculating eGFR.
- Subjects
PAKISTAN; CYSTATIN C; KIDNEY physiology; PEOPLE with diabetes; CREATININE; GLOMERULAR filtration rate
- Publication
Pakistan Armed Forces Medical Journal, 2022, Vol 72, Issue 3, p771
- ISSN
0030-9648
- Publication type
Article
- DOI
10.51253/pafmj.v72i3.6712