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- Title
Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease.
- Authors
Ka Chun Tsui; Roy, Jaydeep; Sze Chun Chau; Kah Hui Wong; Lei Shi; Chi Him Poon; Yingyi Wang; Strekalova, Tatyana; Aquili, Luca; Chuen-Chung Chang, Raymond; Man-Lung Fung; You-qiang Song; Lee Wei Lim
- Abstract
Alzheimer’s disease (AD) is the most common form of dementia. Although previous studies have selectively investigated the localization of amyloid-beta (Aβ) deposition in certain brain regions, a comprehensive characterization of the rostro-caudal distribution of Aβ plaques in the brain and their inter-regional correlation remain unexplored. Our results demonstrated remarkable working and spatial memory deficits in 9-month-old 5xFAD mice compared to wildtype mice. High Aβ plaque load was detected in the somatosensory cortex, piriform cortex, thalamus, and dorsal/ventral hippocampus; moderate levels of Aβ plaques were observed in the motor cortex, orbital cortex, visual cortex, and retrosplenial dysgranular cortex; and low levels of Aβ plaques were located in the amygdala, and the cerebellum; but no Aβ plaques were found in the hypothalamus, raphe nuclei, vestibular nucleus, and cuneate nucleus. Interestingly, the deposition of Aβ plaques was positively associated with brain inter-regions including the prefrontal cortex, somatosensory cortex, medial amygdala, thalamus, and the hippocampus. In conclusion, this study provides a comprehensive morphological profile of Aβ deposition in the brain and its inter-regional correlation. This suggests an association between Aβ plaque deposition and specific brain regions in AD pathogenesis.
- Subjects
BRAIN metabolism; BIOLOGICAL models; SPINAL cord; ALZHEIMER'S disease; ANALYSIS of variance; HIPPOCAMPUS (Brain); ANIMAL experimentation; BASAL ganglia; AMYLOID plaque; NUCLEOTIDES; SOFTWARE architecture; T-test (Statistics); PEARSON correlation (Statistics); THALAMUS; CEREBELLUM; RESEARCH funding; DESCRIPTIVE statistics; DEMENTIA; AMYGDALOID body; NEUROANATOMY; MICE; DISEASE risk factors
- Publication
Frontiers in Aging Neuroscience, 2022, Vol 14, p1
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2022.964336