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- Title
Exposure to SIV in utero results in reduced viral loads and altered responsiveness to postnatal challenge.
- Authors
Baker, Chris A. R.; Swainson, Louise; Lin, Din L.; Samson Wong; Hartigan-O’Connor, Dennis J.; Lifson, Jeffrey D.; Tarantal, Alice F.; McCune, Joseph M.
- Abstract
The article focuses on the examination of nonhuman primate responses to infection by simian immunodeficiency virus (SIV). It mentions that fetal rhesus macaques (Macaca mulatta) were injected with the attenuated virus SIVmac1A11 in utero and had significantly reduced plasma RNA viral loads; immunologic and clinical measurements associated with plasma RNA viral load were identified by generalized estimating equations analysis; and impact of Ki-67int cells on viral load.
- Subjects
SIMIAN immunodeficiency virus; RHESUS monkeys; VIRAL load; SIMIAN immunodeficiency virus diseases vaccines; GENERALIZED estimating equations
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 300, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aac5547