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- Title
Decreased Tissue and Serum Expression of Galectin-7 in Patients with Hypertrophie Scars.
- Authors
Sung Bin CHO; Jun-Sub KIM; Zhenlong ZHENG; Min Ju CHOI; Ihn Geun CHOI; Hong Shik OH; Keun Jae AHN
- Abstract
Hypertrophie scars (HS) result from an imbalance between collagen biosynthesis and matrix degradation during wound healing. In this study a proteomics approach was used to compare the protein profiles of skin tissue obtained from patients with HS and healthy controls. One of the epidermal proteins, galectin-7 was markedly down-regulated in HS. Serum levels of galectin-7 in 27 patients with HS were less than 1/3 of those in 15 healthy controls. Tissue protein expression was subsequently evaluated using immunohistochemical staining on HS tissue and on serially-obtained control tissue during wound healing. Weaker galectin-7 immunoreactivity was detected along the cytoplasmic membrane of basal and suprabasal cells in samples from HS. In addition, galectin-7 was stained in the extracellular space of the upper papillary dermis in HS tissue. Ablative laser treatment, used to induce wound healing of healthy control tissue, demonstrated marked galectin-7 expression at the cytoplasmic membrane on days 3,5,14 and 21. Pronounced galectin-7 staining at the upper papillary dermis was detected on days 1, 3 and 10. These results suggest that the differences in galectin-7 expression and subcellular and extracellular distribution may be crucially involved in the pathogenic process of HS.
- Subjects
WOUND healing; GALECTINS; LECTINS; PROTEINS; BIOMOLECULES
- Publication
Acta Dermato-Venereologica, 2013, Vol 93, Issue 6, p669
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-1583