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- Title
Factor VIII as a Novel Biomarker for Diagnosis, Prognosis, and Therapy Prediction in Human Cancer and Other Disorders.
- Authors
Khalilian, Sheyda; Mohajer, Zahra; Ghafouri-Fard, Soudeh
- Abstract
Coagulation factor VIII (FVIII) is an essential cofactor in the coagulation cascade, encoded by the F8 gene on the long arm of chromosome X (Xq28). FVIII is normally circulated in complex with Von Willebrand factor (VWF) and has relevant emerging ex-tracoagulative functions. Dysregulation of FVIII is associated with tumor progression, and could be used as a novel biomarker for tumor screening and monitoring. In breast cancer, bladder cancer, colorectal carcinoma, esophageal carcinoma, hepatocellular carcinoma and lung cancer, F8 is regarded as an oncogene. In coronary heart disease, hemophilia A and liver disease, F8 dysregulation has been recognized as a potential bi-omarker for disease diagnosis and prognosis. However, the basis of these differential expression levels remains to be understood. In this review, which is a mixture of literature review and bioinformatics analysis we described the biological functions and characteristics of FVIII, and also its expression level in non-malignant disorders and various cancers.
- Subjects
TUMOR treatment; TUMOR risk factors; TUMOR diagnosis; RISK assessment; BLADDER tumors; BREAST tumors; COLORECTAL cancer; BLOOD coagulation factors; BIOINFORMATICS; ONCOGENES; TUMORS; BIOMARKERS; DISEASE progression
- Publication
Avicenna Journal of Medical Biotechnology, 2024, Vol 16, Issue 2, p68
- ISSN
2008-2835
- Publication type
Article
- DOI
10.18502/ajmb.v16i2.14857