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- Title
Resistivity of Ant Nest (Myrmecodia pendans) on Ethanol Fraction Burkitt's Lymphoma Cancer Cells (Invitro) Through Interleukin 8 Angiogenesis Obstacles (Il-8).
- Authors
Achmad, Harun; Horax, Sherly; Ramadhany, Sri; Handayani, Hendrastuti; Pratiwi, Rini; Oktawati, Sri; Faizah, Nurul; Sari, Melyanti
- Abstract
This study aims to know how the inhibitory power of angiogenesis interleukin 8 ethanol fraction of ant nest extract in Burkitt's lymphoma cancer cell culture. The study was conducted in a pure laboratory experimental method using Burkitt's lymphoma cancer cell cultures. Gradual research began with determination, extraction, fractionation, making DMEM medium, activation of Burkitt’s Lymphoma cancer cells, up to cytotoxicity test and angiogenesis inhibition test of flavonoid fraction extract of ant nests. Data were analyzed using twoway ANOVA followed by Post Hoc LSD (Least Significant Difference) test with a significance level of 95%. Cytotoxicity test results showed that the flavonoid ethyl acetate fraction at a concentration of 1000 μg / mL could cause cell death as much as 82.71%, and at the lowest concentration of 7.8125 μg / mL can cause cell death by 39.75% cells. The results of the angiogenesis inhibition test showed a significant change in the expression of interleukin 8 in standard solutions. Changes in the expression of interleukin 8 in ethanol solution and ethyl acetate solution with a concentration of 0 to a concentration of 125 results obtained continued to increase. However, when the ethanol solution with 250 levels, the results obtained decreased from 0.254 to 0.237. Likewise, changes in the expression of interleukin 8 in ethyl acetate solution with a concentration of 250 results obtained decreased from 0.291 to 0.261.
- Subjects
BURKITT'S lymphoma; CANCER cell culture; CANCER cells; PLANT extracts; INTERLEUKIN-8; NEOVASCULARIZATION inhibitors; MYRMECOPHYTES (Plants)
- Publication
Journal of International Dental & Medical Research, 2019, Vol 12, Issue 2, p516
- ISSN
1309-100X
- Publication type
Article