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- Title
Antidepressant effects of ketamine in depressed persons -- A short review.
- Authors
Swetha, S.; Priya, Jothi
- Abstract
The purpose of this review is to evaluate the effects of ketamine in depressed patients, which makes it a valuable research tool to identify the response and develop the next generation of fast-acting antidepressants. A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of major depression and the mechanism of action of antidepressants. The review aims to assess the treatment effects of a single dose of an N-methyl-d-aspartate (NMDA) receptor antagonist in patients with depression. The NMDA antagonist ketamine, fast-acting antidepressants, has consistently shown antidepressant effects within a few hours of its administration. The ketamine can exert their antidepressant effects within hours or a few days of their administration. It is a better understanding of the presumed mechanisms associated with these rapid antidepressant effects.
- Subjects
KETAMINE; DEPRESSED persons; ANTIDEPRESSANTS; MENTAL depression; TREATMENT effectiveness; BIOCHEMICAL mechanism of action
- Publication
Drug Invention Today, 2020, Vol 13, Issue 1, p110
- ISSN
0975-7619
- Publication type
Article