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- Title
Molecular mechanisms and therapeutic approaches to the treatment of African Trypanosomiasis.
- Authors
Natuva, D. P.; Brahmani, S.; Subbarao, K.; Padma, B.; Anil, B.; Koppulo, Sunilbabu; Rao, Ch Babu
- Abstract
Human African trypanosomiasis, or sleeping sickness, is a neglected vector-borne parasitic disease caused by protozoa of the species Trypanosome Brucesensu lato. Within this complex species, T. B. gambiense is responsible for the chronic form of sleeping sickness In Western and Central Africa, whereas T. B. rhodesiense causes the acute form of the disease in East Africa. Presently, 1.5 million disability-adjusted life years (DALYs) per year are lost due to sleeping sickness. In addition, on the basis of the mortality, the disease is ranked ninth out of 25 human infectious and parasitic diseases in Africa. Diagnosis is complex and needs the intervention of a specialized skilled staff. Treatment is difficult and expensive and has potentially life-threatening side effects. The use of transcriptomic and proteometechnologies, currently in rapid development and increasing in sensitivity and discriminating power is already generating a large panel of promising results. The present review highlights the contributions of the transcriptomic and proteomic analyses developed thus far in order to identify potential targets (genes or proteins) and biological pathways that may constitute a critical step in the identification of new targets for the development of new tools for diagnostic and therapeutic purposes of Human African trypanosomiasis. This was all so carried by tis-tis fly, due to when it is injected protozoa in the human body, it will make a sound that is Tis..Tis..
- Subjects
MOLECULAR biology; THERAPEUTICS; TREATMENT of African trypanosomiasis; TRYPANOSOMATIDAE; PROTOZOA; MORTALITY
- Publication
Drug Invention Today, 2012, Vol 4, Issue 5, p381
- ISSN
0975-7619
- Publication type
Article