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- Title
Effect of Rhus tox and Causticum on rat adjuvant arthritis.
- Authors
Sukul, Anirban; Sukul, Nirmal Chandra
- Abstract
Introduction: Homeopathic drug like Causticum 30c and Rhus tox 30c have long been used for the treatment of arthritic patients. While Causticum acts more or less on both sides of the body, Rhus tox is more left-sided in its action. In the present study we tested the anti-arthritic and anti-nociceptive effect of Causticum 30c and Rhus tox 30c on the rat model. Material and Methods: Fifty male albino rats of Charles Foster strain weighing 65-120g were divided into 5 batches and were kept in an animal house at a room temperature 26±2°C. all the animals were handled with extreme care and were approved by the Animal Ethics Committee of the University. Treatment: Arthritis was induced by injecting 0.1 ml of FCA, purchased from GENEI, Bangalore, in the plantar region of the hind paw of left leg in batches II, III and IV and that of the right leg in batch V on day 0.Batch I remained untreated and uninjected. Batch II was injected and untreated (Placebo, Ethanol 30). Batches III and V received Causticum 30c orally, one dose daily, from day 2 to day 18. Batch IV received Rhus tox 30c during the same period. Each potency was mixed with sterile distilled water 1:100 and administered orally by a micropipette at 100μl/rat. The control consisted of Ethanol 30c prepared in the same way. Observations: (1) Measurement of paw volume; (2) Open field activity; (3) Movement on an inclined wire grid were taken. Results: Paw volumes increased significantly (p <0.01, Mann-Whitney U-test) on day 14 in all FCA-injected batches as compared to the uninjected untreated control batch. Compared with the batch II (untreated) paw volume was significantly reduced in left paw injected Rhus tox 30c -treated batch IV (p < 0.01) and right paw -injected Causticum 30c-treated batch V (p <0.02). The locomotor activity was significantly higher in batch III, batch IV and batch V as compare to the untreated batch II. Movement scores on the inclined wire grid were significantly higher in batches III, IV and V (p< 0.05) as compared to the injected untreated batch II. Conclusions: It is evident from the results that both Causticum 30c and Rhus tox 30c produced anti-inflammatory effect with respect to the FCA-induced edema in paws. Both the drugs produce significant anti-nociceptive effect as is evident from the results of the two locomotor activity tests. The drug treated rats performed better in these two tests as compared to the placebo control and this might be due to amelioration of pain in affected paw to some extent.
- Subjects
POISON oak; LABORATORY rats; RHEUMATOID arthritis; TREATMENT of arthritis; DISTILLED water; PAIN management
- Publication
International Journal of High Dilution Resarch, 2013, Vol 12, Issue 44, p135
- ISSN
1982-6206
- Publication type
Article