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- Title
Microcephaly in Infants: A Retrospective Cohort Study from Turkey.
- Authors
Keskindemirci, Gonca; Aşkan, Öykü Özbörü; Selver, Burak; Kayı, Alev Bakır; Gökçay, Gülbin
- Abstract
Objective: Microcephaly (MC) is a clinical finding mostly reflecting deficiency of brain growth. The aim of this retrospective cohort study was to assess risk factors and follow-up features of children with MC. Methods: Children’s personal health records (n=7580) followed between 2002 and 2020 in the Unit of a Well Child Clinic were assessed retrospectively. The case group comprised children with MC. MC was defined as head circumference (HC) standard deviation score (SDS) value ≤-2 SDS. Age and sex-matched children with normal HC were selected as the control group. Results: Children with MC (n=49) had more disadvantaged sociodemographic characteristics, such as young maternal and paternal age and low maternal and paternal education. Breastfeeding was more common among controls (n=98). Resolution of MC was observed in 26 (53.1%) children with MC, whether it was mild (HC SDS between -2 and -2.9) or severe (HC SDS ≤3). Children with persistent MC had poorer developmental milestones than controls and cases with resolution. Sociodemographic features or developmental milestones in mild and severe MC did not differ. Conclusion: These results suggest that the use of a definition of MC of ≤-2 SDS would be appropriate in order not to miss cases on follow-up. Greater sociodemographic equality may prevent some cases of MC. Further studies are needed evaluating socioeconomic factors on MC.
- Subjects
TURKEY; MICROCEPHALY; RISK assessment; PATERNAL age effect; BREASTFEEDING; INFANT development; NEURAL development; RETROSPECTIVE studies; CEPHALOMETRY; DESCRIPTIVE statistics; LONGITUDINAL method; MEDICAL records; SOCIODEMOGRAPHIC factors; DISEASE risk factors; CHILDREN
- Publication
Journal of Clinical Research in Pediatric Endocrinology, 2024, Vol 16, Issue 2, p168
- ISSN
1308-5727
- Publication type
Article
- DOI
10.4274/jcrpe.galenos.2024.2023-5-3