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- Title
Nukleozydo boranofosfoniany jako potencjalne środki terapeutyczne.
- Authors
Filipiak, Eliza; Gołębiewska, Justyna
- Abstract
Nucleoside boranephosphonates are nucleotide analogues in which one of the non-bridging oxygen atom of the phosphate part has been replaced by a borane group (-BH3). This modification imparts a wide spectrum of biological activity, e.g., activation of ribonuclease H, resistance to endo- and exonucleases, and their respective triphosphates are good substrates for DNA and RNA polymerases. Nucleoside boranephosphonate derivatives are used in antisense therapy, silencing gene expression using siRNA strategies, and as potential antiviral and anti-cancer prodrugs. Boranephosphonates find also applications as aptamers and as substrates in a new method of DNA sequencing. This review briefly presents potential biological applications of nucleoside boranephosphonates.
- Subjects
RIBONUCLEASE H; RNA polymerases; GENE silencing; NUCLEOSIDE derivatives; DNA sequencing; APTAMERS
- Publication
Advances in Biochemistry / Postepy Biochemii, 2022, Vol 68, Issue 2, p142
- ISSN
0032-5422
- Publication type
Article
- DOI
10.18388/pb.2021_425