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- Title
Donor-derived Ehrlichiosis: 2 Clusters Following Solid Organ Transplantation.
- Authors
Saha, Aditi; Browning, Charles; Dandamudi, Raja; Barton, Kevin; Graepel, Kevin; Cullity, Madeline; Abusalah, Wala; Christine, Du; Rossi, Carla; Drexler, Naomi; Basavaraju, Sridhar V; Annambhotia, Pallavi; Guillamet, Rodrigo Vazquez; Eid, Albert J; Maliakkal, Joseph; Miller, Aaron; Hugge, Christopher; Dharnidharka, Vikas R; Kandula, Praveen; Moritz, Michael J
- Abstract
Ehrlichiosis has been infrequently described as transmissible through organ transplantation. Two donor-derived clusters of ehrlichiosis are described here. During the summer of 2020, 2 cases of ehrlichiosis were reported to the Organ Procurement and Transplantation Network (OPTN) and the Centers for Disease Control and Prevention (CDC) for investigation. Additional transplant centers were contacted to investigate similar illness in other recipients and samples were sent to the CDC. Two kidney recipients from a common donor developed fatal ehrlichiosis-induced hemophagocytic lymphocytic histiocytosis. Two kidney recipients and a liver recipient from another common donor developed ehrlichiosis. All 3 were successfully treated. Clinicians should consider donor-derived ehrlichiosis when evaluating recipients with fever early after transplantation after more common causes are ruled out, especially if the donor has epidemiological risk factors for infection. Suspected cases should be reported to the organ procurement organization and the OPTN for further investigation by public health authorities.
- Subjects
UNITED States; ACQUISITION of data methodology; HEMOPHAGOCYTIC lymphohistiocytosis; FEVER; BIOPSY; AUTOPSY; LIVER; LUNGS; RETROSPECTIVE studies; KIDNEY transplantation; POSTOPERATIVE care; INTERVIEWING; RICKETTSIA; DNA probes; MEDICAL records; LIVER transplantation; POLYMERASE chain reaction; BONE marrow; EHRLICHIOSIS; TRANSPLANTATION of organs, tissues, etc.; INFECTIOUS disease transmission; SYMPTOMS
- Publication
Clinical Infectious Diseases, 2022, Vol 74, Issue 5, p918
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciab667