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- Title
Improved osteoblast adhesion and osseointegration on TiO2 nanotubes surface with hydroxyapatite coating.
- Authors
Ying LI; Baoe LI; Yunjia SONG; Aobo MA; Changyi LI; Xu ZHANG; Hongjie LI; Qian ZHANG; Kai ZHANG
- Abstract
To improve initial osteoblast adhesion and subsequent osseointegration, TiO2 nanotubes layer was constructed on the titanium (Ti) surface by anodic oxidation (AO), with an additional hydroxyapatite (HA) coating to form the AO/HA surface. Tests on in vitro cellular activity displayed that the AO surface, especially the AO/HA surface, promoted initial adhesion, proliferation and differentiation of osteoblast cells. The modified AO and AO/HA surfaces further presented an up-regulated gene expression of osteogenic and adhesion markers collagen type 1 (COL), osteopontin (OPN), osteocalcin (OCN) and vinculin. In addition, in vivo experiments with a rat model demonstrated that the AO surface, particularly the AO/HA surface, achieved earlier osseointegration and a superior bone bonding ability compared with Ti. Our study shed light on a synergistic role played by nanotopography and HA in promoting osteoblast adhesion, proliferation, differentiation and osseointegration, thus suggesting a promising method for better modifying the implant surface.
- Subjects
OSTEOBLASTS; DENTAL adhesives; TITANIUM dioxide nanoparticles; HYDROXYAPATITE coating; OSSEOINTEGRATION
- Publication
Dental Materials Journal, 2019, Vol 38, Issue 2, p278
- ISSN
0287-4547
- Publication type
Article
- DOI
10.4012/dmj.2018-118