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- Title
Preparation of Sr-containing carbonate apatite as a bone substitute and its properties.
- Authors
Sakai, Akiko; Valanezahad, Alireza; Ozaki, Masao; Ishikawa, Kunio; Matsuya, Shigeki
- Abstract
Sr-containing carbonate apatite (SrCAp) specimens of varied Sr contents, ranging from 0 to 13.3 mol%, were prepared through a phosphate treatment of set gypsum-and-carbonate mixture at 100°C for 7 days. Effects of Sr content in SrCAp on microstructure, osteoblast-like cell (MC3T3-E1) attachment and proliferation, and alkaline phosphatase (ALP) activity were evaluated. Sr2+ ion substituted Ca2+ ion in the apatite lattice. Carbonate content was about 9-13.6 wt%, increasing in content level as Sr content increased. Sr addition benefited cell attachment but had no significant influence on cell proliferation, although the latter was inhibited at the highest Sr content. ALP activity reached a peak in specimen containing 3.4 mol% of Sr. The present study revealed that SrCAp is a promising candidate for use as a bone substitute material with good resorbabilty and osteoconductivity.
- Subjects
STRONTIUM; CARBONATES; APATITE in the body; CELL proliferation; ALKALINE phosphatase; DENTAL materials
- Publication
Dental Materials Journal, 2012, Vol 31, Issue 2, p197
- ISSN
0287-4547
- Publication type
Article
- DOI
10.4012/dmj.2011-177