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- Title
Cerebrospinal fluid monoamine metabolites in cocaine patients: no relationship to cue-induced craving.
- Authors
Roy M.D., Alec; Berman, Jeffrey; Gonzalez, Bienvenido; Roy, Monique; Roy, Alec
- Abstract
We aimed to examine the relationship between central monoamine metabolites and craving cocaine in cocaine-dependent patients. Cerebrospinal fluid (CSF) monoamine metabolite concentrations were determined in 20 withdrawn cocaine-dependent patients. Patients also participated in a cue-elicited cocaine craving procedure. There were no significant relationships between cocaine craving scores and CSF concentrations of the dopamine metabolite, homovanillic acid, the serotonin metabolite, 5-hydroxyindoleacetic acid, or the norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylglycol. CSF monoamine metabolite concentrations were not related to cocaine craving in withdrawn cocaine-dependent patients.
- Subjects
CEREBROSPINAL fluid; MONOAMINE oxidase; COCAINE; DOPAMINE; NORADRENALINE; SUBSTANCE abuse &; psychology; COMPARATIVE studies; DRUG withdrawal symptoms; RESEARCH methodology; MEDICAL cooperation; MOTIVATION (Psychology); RESEARCH; SEROTONIN; SUBSTANCE abuse; SUBSTANCE abuse treatment; TREATMENT programs; EVALUATION research; ETHYLENE glycols; PROMPTS (Psychology); CARBOCYCLIC acids; INDOLE compounds; PSYCHOLOGY
- Publication
Journal of Psychopharmacology, 2002, Vol 16, Issue 3, p227
- ISSN
0269-8811
- Publication type
journal article
- DOI
10.1177/026988110201600306