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- Title
Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study.
- Authors
Yoon, Sung-Wook; Kim, Myong-Ji; Paeng, Kyeong-Won; Yu, Kyeong Ae; Lee, Chong-Kil; Song, Young Woo; Cha, Jae-Kook; Sanz, Mariano; Jung, Ui-Won
- Abstract
Background: The objective of this is preclinical investigation was to evaluate the differential drug sustainability and pharmacodynamic properties of two local minocycline microsphere carriers: chitosan-coated alginate (CA) and poly(meth)acrylate-glycerin (PG). Methods: Four dental implants were placed unilaterally in the edentulous mandible of six beagle dogs. Each implant was randomly assigned to receive one of the following four treatments: (i) CA (CA-based minocycline), (ii) placebo (CA substrate without minocycline), (iii) PG (PG-based minocycline) and (iv) control (mechanical debridement only). After inducing peri-implant mucositis, the randomly assigned treatments were administered into the gingival sulcus twice at a 4-week interval using a plastic-tipped syringe. Drug sustainability and pharmacodynamic (clinical, radiographical and cell marker intensity) evaluations were performed after each administration. Results: The CA microspheres remained longer around the healing abutment compared to the PG microspheres at both administrations and a longer bacteriostatic effect was observed from CA (7.0 ± 5.7 days) compared to PG (1.2 ± 2.6 days). The efficacy of the applied therapies based on clinical, radiographical and histological analyses were comparable across all treatment groups. Conclusions: CA microspheres showed longer carrier and bacteriostatic effect sustainability when compared to PG microspheres, however, longer drug sustainability did not lead to improved treatment outcomes.
- Subjects
MINOCYCLINE; MICROSPHERES; MUCOSITIS; ACRYLATES; PLACEBOS; BEAGLE (Dog breed); METHAMPHETAMINE; MELPHALAN
- Publication
Pharmaceutics, 2020, Vol 12, Issue 7, p668
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics12070668