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- Title
Bared essentials of CDK2 and cyclin E.
- Authors
Roberts, James M.; Sherr, Charles J.
- Abstract
The cyclin E-CDK2 complex was thought to be an essential regulator of the mitotic cell cycle. Oscillations in the activities of cyclin-dependent kinases (CDKs) dictate orderly progression through the cell division cycle. A progressive rise in the activity of a single cyclin-CDK complex can initiate DNA synthesis and then mitosis, and the subsequent fall in CDK activity resets the system for the next cell cycle1. For the mammalian somatic cell cycle, the current thinking is that cyclins E and A, in combination with CDK2, initiate chromosome and centrosome duplication, whereas subsequent activation of cyclin A- and cyclin B-driven CDK1 complexes governs later events that terminate with mitosis.
- Subjects
CYCLIN-dependent kinases; MITOSIS; CYCLINS; CELL cycle; DNA
- Publication
Nature Genetics, 2003, Vol 35, Issue 1, p8
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1234