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- Title
The Association of Elevated HDL Levels With Carotid Atherosclerosis in Middle-Aged Women With Untreated Essential Hypertension.
- Authors
Triantafyllidi, Helen; Pavlidis, George; Trivilou, Paraskevi; Ikonomidis, Ignatios; Tzortzis, Stavros; Xenogiannis, Iosif; Schoinas, Antonios; Lekakis, John
- Abstract
High-density lipoprotein cholesterol (HDL-C), a negative risk factor, is positively associated with a decreased risk of coronary heart disease. We investigated the association between high HDL-C levels and target organ damage (TOD) in never treated women with hypertension. We measured HDL-C levels in 117 women followed by estimation of TODs, that is, pulse wave velocity, microalbuminuria, left ventricular mass index, coronary flow reserve, and carotid intima–media thickness (cIMT). Women were divided into 2 groups (HDLH and HDLL), regarding HDL-C quartiles (upper quartile vs the first 3 lower quartiles). In HDLH group (HDL ≥70 mg/dL), cIMT was nonindependently, negatively related to HDL-C (ρ = −.42, P < .05). Using receiver –operating characteristic curve (ROC) analysis in the HDLH group, we concluded that the cutoff value of HDL ≥76.5 mg/dL moderately predicted the absence of carotid atherosclerosis (area under the curve: 0.77, P = .02; confidence interval: 0.57-0.97; sensitivity 73% and specificity 67%). Increased HDL-C may predict the absence of carotid atherosclerosis in middle-age women with untreated essential hypertension and consequently contribute to total cardiovascular risk estimation and treatment planning.
- Subjects
GREECE; ATHEROSCLEROSIS risk factors; CAROTID artery diseases; HYPERTENSION; AMBULATORY blood pressure monitoring; CARDIOVASCULAR disease diagnosis; CARDIOVASCULAR diseases risk factors; CONFIDENCE intervals; ECHOCARDIOGRAPHY; HIGH density lipoproteins; REFERENCE values; REGRESSION analysis; T-test (Statistics); WOMEN'S health; RECEIVER operating characteristic curves; DATA analysis software; DESCRIPTIVE statistics; DISEASE risk factors
- Publication
Angiology, 2015, Vol 66, Issue 10, p904
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319715572679