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- Title
Mouse retrotransposons: sequence structure, evolutionary age, genomic distribution and function.
- Authors
Masaki Kawase; Kenji Ichiyanagi
- Abstract
Retrotransposons are transposable elements that are transposed via transcription and reverse transcription. Their copies have accumulated in the genome of mammals, occupying approximately 40% of mammalian genomic mass. These copies are often involved in numerous phenomena, such as chromatin spatial organization, gene expression, development and disease, and have been recognized as a driving force in evolution. Different organisms have gained specific retrotransposon subfamilies and retrotransposed copies, such as hundreds of Mus-specific subfamilies with diverse sequences and genomic locations. Despite this complexity, basic information is still necessary for present-day genomic and epigenomic studies. Herein, we describe the characteristics of each subfamily of Mus-specific retrotransposons in terms of sequence structure, phylogenetic relationships, evolutionary age, and preference for A or B compartments of chromatin.
- Subjects
RETROTRANSPOSONS; GENE expression; MICE; CHROMATIN; GENOMES; AGE
- Publication
Genes & Genetic Systems, 2023, Vol 98, Issue 6, p337
- ISSN
1341-7568
- Publication type
Article
- DOI
10.1266/ggs.23-00221