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- Title
Induced Osteogenesis in the Repair of Experimental Mandibular Defects in Rats.
- Authors
KABAN, LEONARD B.; GLOWACKI, JULIE
- Abstract
In order to investigate the repair of mandibular defects, we have devised a nonhealing model in the ramus of the rat mandible. The large full-thickness defects, devoid of periosteum, were filled with demineralized bone powder (DBP), lyophilized bone chips, and un-demineralized bone powder (BP) or were irrigated with Ringer's lactate. Healing was judged by gross and histologic examination and by incorporation of 45calcium into hydroxyapatite. DBP produced more rapid and complete healing than did BP or lyophilized chips. DBP did not undergo appreciable resorption prior to bone formation and was a more potent osteogenic stimulus than was BP or lyophilized chips.
- Subjects
MANDIBLE; BONE growth; RATS; HYDROXYAPATITE; HEALING; RESORPTION (Physiology)
- Publication
Journal of Dental Research, 1981, Vol 60, Issue 7, p1356
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/00220345810600071201