We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Metabolic Fingerprints of Circulating IGF-1 and the IGF-1/IGFBP-3 Ratio: A Multifluid Metabolomics Study.
- Authors
Knacke, Henrike; Pietzner, Maik; Do, Kieu Trinh; Römisch-Margl, Werner; Kastenmüller, Gabi; Völker, Uwe; Völzke, Henry; Krumsiek, Jan; Artati, Anna; Wallaschofski, Henri; Nauck, Matthias; Suhre, Karsten; Adamski, Jerzy; Friedrich, Nele
- Abstract
Objective: IGF-1 is known for its various physiological and severe pathophysiological effects on human metabolism; however, underlying molecular mechanisms still remain unsolved. To reveal possible molecular mechanisms mediating these effects, for the first time, we associated serum IGF-1 levels with multifluid untargeted metabolomics data. Methods: Plasma/urine samples of 995 nondiabetic participants of the Study of Health in Pomerania were characterized by mass spectrometry. Sex-specific linear regression analyses were performed to assess the association of IGF-1 and IGF-1/IGF binding protein 3 ratio with metabolites. Additionally, the predictive ability of the plasma and urine metabolome for IGF-1 was assessed by orthogonal partial least squares analyses. Results and Conclusions: We revealed a multifaceted image of associated metabolites with large sex differences. Confirming previous reports, we detected relations between IGF-1 and steroid hormones or related intermediates. Furthermore, various associated metabolites were previously mentioned regarding IGF-1-associated diseases, eg, betaine and cortisol in cardiovascular disease and metabolic syndrome,lipiddisorders, anddiabetes,orhavepreviouslybeen found to associatewithdifferentiation and proliferation or mitochondrial functionality, eg, phospholipids. bradykinin, fatty acid derivatives, and cortisol, which were inversely associated with IGF-1, might establish a link of IGF-1 with inflammation. For the first time,we showed an association betweenIGF-1 and pipecolate, ametabolitelinked to amino acid metabolism. Our study demonstrates that IGF-1 action on metabolism is tractable, even in healthy subjects, and that the findings provide a solid basis for further experimental/clinical investigation, eg, searching for inflammatory or cardiovascular disease- or metabolic syndromeassociated biomarkers and therapeutic targets. (J Clin Endocrinol Metab 101: 4730 – 4742, 2016)
- Subjects
GERMANY; BIOCHEMISTRY; CARRIER proteins; METABOLISM; SEX distribution; SOMATOMEDIN; ACQUISITION of data
- Publication
Journal of Clinical Endocrinology & Metabolism, 2016, p4730
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2016-2588