We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Asymmetric Bio- and Chemoreduction of 2-Benzylidenecyclopentanone Derivatives.
- Authors
Štefane, Bogdan; Grošelj, Uroš; Svete, Jurij; Požgan, Franc
- Abstract
Highly efficient asymmetric reduction of 2-benzylidenecyclopentanone derivatives to give the respective exocyclic allylic alcohols in ee's up to 96% was performed with chiral oxazaborolidine-based catalysts. Complete enantioselectivity furnishing (S)-configured alcohol product could be achieved by bioreduction of 2-(4-chlorobenzylidene)cyclopentanone with Daucus carota root. The synthesized compounds may be used as enantiomerically enriched standards for the monitoring of the enzyme-catalyzed redox processes.
- Subjects
CYCLOPENTANONES; CARROTS; DAUCUS; ALLYLIC alkylation; SUBSTITUTION reactions
- Publication
Acta Chimica Slovenica, 2017, Vol 64, Issue 4, p727
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2017.3543