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- Title
In Silico Study of Plant Polyphenols' Interactions with VP24-Ebola Virus Membrane-associated Protein.
- Authors
Pleško, Sebastian; Volk, Helena; Lukšič, Miha; Podlipnik, Črtomir
- Abstract
The Zaire Ebola viral protein VP24 selectively inhibits nuclear import of STAT1 and as such blocks interferon-induced antiviral responses vital for cell's emergency. Inhibition of VP24 with small molecule inhibitor may neutralize the threatening action of Ebola virus. We performed molecular docking of compounds from a selected small library of plant polyphenols on to VP24. Our research shows that 1,2,3,6-tetragalloyl glucose, epigallocatechin gallate, chlorogenic acic, oleuropein and miquelianin represent promising leads for further studies.
- Subjects
POLYPHENOLS; EBOLA virus; MEMBRANE proteins; EPIGALLOCATECHIN gallate; INTERFERONS
- Publication
Acta Chimica Slovenica, 2015, Vol 62, Issue 3, p555
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2015.1505