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- Title
New and Repurposed Drugs for Pediatric Multidrug-Resistant Tuberculosis. Practice-based Recommendations.
- Authors
Harausz, Elizabeth P.; Garcia-Prats, Anthony J.; Seddon, James A.; Schaaf, H. Simon; Hesseling, Anneke C.; Achar, Jay; Bernheimer, Jonathan; Cruz, Andrea T.; D’Ambrosio, Lia; Detjen, Anne; Graham, Stephen M.; Hughes, Jennifer; Jonckheere, Sylvie; Marais, Ben J.; Migliori, Giovanni Battista; McKenna, Lindsay; Skrahina, Alena; Tadolini, Marina; Wilson, Peyton; Furin, Jennifer
- Abstract
It is estimated that 33,000 children develop multidrug-resistant tuberculosis (MDR-TB) each year. In spite of these numbers, children and adolescents have limited access to the new and repurposed MDR-TB drugs. There is also little clinical guidance for the use of these drugs and for the shorter MDR-TB regimen in the pediatric population. This is despite the fact that these drugs and regimens are associated with improved interim outcomes and acceptable safety profiles in adults. This review fills a gap in the pediatric MDR-TB literature by providing practice-based recommendations for the use of the new (delamanid and bedaquiline) and repurposed (linezolid and clofazimine) MDR-TB drugs and the new shorter MDR-TB regimen in children and adolescents.
- Publication
American Journal of Respiratory & Critical Care Medicine, 2017, Vol 195, Issue 10, p1300
- ISSN
1073-449X
- Publication type
journal article
- DOI
10.1164/rccm.201606-1227CI