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- Title
Circulating Levels of Allopregnanolone, an Anticonvulsant Metabolite of Progesterone, in Women with Partial Epilepsy in the Postcritical Phase.
- Authors
Galli, Renato; Luisi, Michele; Pizzanelli, Chiara; Monteleone, Patrizia; Casarosa, Elena; Iudice, Alfonso; Murri, Luigi
- Abstract
Purpose: Several lines of evidence indicate that there exists a relation between ovarian hormones and epilepsy. Estrogens decrease seizure threshold and increase brain excitability, whereas progesterone has an inhibitory effect and reduces epileptiform activity. Recently considerable interest has turned to neuroactive steroids, a group of progesterone metabolites, as endogenous modulators of excitability of the central nervous system (CNS). Their ability to alter neuronal firing rapidly occurs through interaction with γ-aminobutyric acid (GABA) A receptor complex. In a previous experience, serum allopregnanolone (3α-OH-5α-pregnan-20-one) levels were measured in 15 women with partial epilepsy in the intercritical phase, and no significant differences were found between patients and control subjects...
- Subjects
TREATMENT of epilepsy; ANTICONVULSANTS
- Publication
Epilepsia (Series 4), 2001, Vol 42, Issue 2, p216
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1046/j.1528-1157.2001.4220216.x