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- Title
Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study).
- Authors
Scherbakov, Nadja; Ebner, Nicole; Sandek, Anja; Meisel, Andreas; Haeusler, Karl Georg; von Haehling, Stephan; Anker, Stefan D.; Dirnagl, Ulrich; Joebges, Michael; Doehner, Wolfram
- Abstract
<bold>Background: </bold>Patients with stroke are at a high risk for long-term handicap and disability. In the first weeks after stroke muscle wasting is observed frequently. Early post-stroke rehabilitation programs are directed to improve functional independence and physical performance. Supplementation with essential amino acids (EAAs) might prevent muscle wasting and improve rehabilitation outcome by augmenting muscle mass and muscle strength. We aim to examine this in a double blinded, randomized placebo-controlled clinical trial.<bold>Methods: </bold>Patients with ischemic or haemorrhagic stroke will be enrolled at begin of the early post-stroke rehabilitation in a parallel group interventional trial. Oral supplementation of EAAs or placebo will be given for 12 weeks in a double blinded manner. Physical and functional performance will be assessed by exercise testing before supplementation of EAAs as well as at discharge from the in-patient rehabilitation, at 12 weeks and 1 year afterwards.<bold>Discussion: </bold>This is the first randomized double-blinded placebo-controlled clinical study aiming to assess the effect of the EAAs supplementation on muscle strength, muscle function and physical performance in stroke patients during early post-stroke rehabilitation. Supplementation of EAAs could prevent muscle mass wasting and improve functional independence after stroke.<bold>Trial Registration: </bold>The study is registered at the German registry for clinical trials as well as at World Health Organization (WHO; number DRKS00005577).
- Subjects
STROKE treatment; MEDICAL rehabilitation; SKELETAL muscle injuries; ESSENTIAL amino acids; MUSCLE strength measurement; THERAPEUTICS; CLINICAL trials; MEDICAL protocols; MUSCLE strength; HEALTH outcome assessment; STROKE; RANDOMIZED controlled trials; SKELETAL muscle; STROKE rehabilitation
- Publication
BMC Neurology, 2016, Vol 16, p1
- ISSN
1471-2377
- Publication type
journal article
- DOI
10.1186/s12883-016-0531-5