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- Title
Upstream Pathways Controlling Mitochondrial Function in Major Psychosis: A Focus on Bipolar Disorder.
- Authors
Kolinski Machado, Alencar; Yongshuai Pan, Alexander; Morgana da Silva, Tatiane; Duong, Angela; Andreazza, Ana Cristina; Machado, Alencar Kolinski; Pan, Alexander Yongshuai; da Silva, Tatiane Morgana
- Abstract
Mitochondrial dysfunction is commonly observed in bipolar disorder (BD) and schizophrenia (SCZ) and may be a central feature of psychosis. These illnesses are complex and heterogeneous, which is reflected by the complexity of the processes regulating mitochondrial function. Mitochondria are typically associated with energy production; however, dysfunction of mitochondria affects not only energy production but also vital cellular processes, including the formation of reactive oxygen species, cell cycle and survival, intracellular Ca(2+) homeostasis, and neurotransmission. In this review, we characterize the upstream components controlling mitochondrial function, including 1) mutations in nuclear and mitochondrial DNA, 2) mitochondrial dynamics, and 3) intracellular Ca(2+) homeostasis. Characterizing and understanding the upstream factors that regulate mitochondrial function is essential to understand progression of these illnesses and develop biomarkers and therapeutics.
- Subjects
MITOCHONDRIAL pathology; BIPOLAR disorder; SCHIZOPHRENIA -- Physiological aspects; MITOCHONDRIAL physiology; GENETIC mutation; INTRACELLULAR calcium; PHYSIOLOGY
- Publication
Canadian Journal of Psychiatry, 2016, Vol 61, Issue 8, p446
- ISSN
0706-7437
- Publication type
journal article
- DOI
10.1177/0706743716648297