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- Title
All plugged up - noninvasive mucus score to assess airway dysfunction in asthma.
- Authors
Georas, Steve N.
- Abstract
Asthma is remarkably heterogeneous, and there are multiple underlying inflammatory pathways and structural airway abnormalities that lead to symptomatic disease. Consequently, a current challenge in the field is to precisely characterize different types of asthma, with the goal of developing personalized approaches to therapy. In the current issue of the JCI, Dunican et al. developed a noninvasive way to assess airway dysfunction in asthma by measuring mucus accumulation using multidetector computed tomography (MDCT) and found that mucus plugging of small airways was remarkably common in subjects with severe asthma. This work highlights the importance of noninvasive imaging approaches in defining specific asthma subsets and guiding targeted therapies.
- Subjects
ASTHMA treatment; NONINVASIVE diagnostic tests; INFLAMMATORY mediators; RESPIRATORY obstructions; AIRWAY (Anatomy); MUCUS; MULTIDETECTOR computed tomography; ASTHMA; EOSINOPHILIA; LUNGS
- Publication
Journal of Clinical Investigation, 2018, Vol 128, Issue 3, p906
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI99726