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- Title
Characterization of Fractionation Membranes in an Animal Model of Double Filtration Lipoprotein Apheresis.
- Authors
Krieter, Detlef H.; Lange, Florian; Lemke, Horst‐Dieter; Bonn, Florian; Wanner, Christoph
- Abstract
Abstract: Technical problems during clinical lipid apheresis interfere with fractionator performance. Therefore, a large animal model was established to characterize a new plasma fractionation membrane. Four sheep were randomized, controlled, and crossover subjected to double ofiltration lipoprotein apheresis with three specimens of FractioPESR having slightly different HDL sieving coefficients (<italic>SK</italic>) (FPESa, 0.30, FPESb, 0.26, and FPESc, 0.22) versus a control fractionator (EVAL). <italic>SK</italic> and reduction ratios were determined for LDL, HDL, fibrinogen, IgG, and albumin. Compared to EVAL (0.42 ± 0.04 to 0.74 ± 0.08) and FPESa (0.36 ± 0.06 to 0.64 ± 0.04), <italic>SK</italic> for HDL were lower (<italic>P</italic> < 0.05) with FPESc (0.30 ± 0.04 to 0.49 ± 0.10). Fibrinogen <italic>SK</italic> were higher (<italic>P</italic> < 0.05) with EVAL (0.02 ± 0.01 to 0.40 ± 0.08) compared to FPESb (0.05 ± 0.02 to 0.26 ± 0.34) and FPESc (0.01 ± 0.01 to 0.21 ± 0.16). No further differences were determined. The animal model distinguished between minor differences in fractionation membrane permeability, demonstrating equivalent sieving of FPESa and EVAL and slightly inferior permeability of FPESb and FPESc.
- Publication
Therapeutic Apheresis & Dialysis, 2018, Vol 22, Issue 2, p189
- ISSN
1744-9979
- Publication type
Article
- DOI
10.1111/1744-9987.12649