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- Title
The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela.
- Authors
Viala, Vincent Louis; Slavov, Svetoslav Nanev; de Lima, Loyze Paola Oliveira; Lima, Alex Ranieri Jeronimo; Ribeiro, Gabriela; Martins, Antonio Jorge; Petry, Bruna; Banho, Cecilia Artico; Barros, Claudia Renata dos Santos; Moncau, Cristina Tschorny; Moretti, Debora Botequio; de La-Roque, Debora Glenda Lima; Marqueze, Elaine Cristina; Mattos, Elisangela Chicaroni; Costa, Felipe Allan da Silva da; Fukumasu, Heidge; Bernardino, Jardelina de Souza Todao; Souza-Neto, Jayme A.; Lesbon, Jessika Cristina Chagas; Kayanoki, Lara Passos
- Abstract
Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations.
- Subjects
BRAZIL; SAO Paulo (Brazil : State); SARS-CoV-2; INFECTIOUS disease transmission; ISLANDS; BRAZILIANS; MOLECULAR epidemiology
- Publication
Viruses (1999-4915), 2022, Vol 14, Issue 7, pN.PAG
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v14071481