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- Title
<italic>ortho</italic>‐Quinones and Analogues Thereof: Highly Reactive Intermediates for Fast and Selective Biofunctionalization.
- Authors
Bruins, Jorick J.; Albada, Bauke; van Delft, Floris
- Abstract
Abstract: Fast, selective and facile functionalization of biologically relevant molecules is a pursuit of ever‐growing importance. A promising approach in this regard employs the high reactivity of quinone and quinone analogues for fast conjugation chemistry by nucleophilic addition or cycloadditions. Combined with in situ generation of these compounds, selective conjugation on proteins and surfaces can be uniquely induced in a time and spatially resolved manner: generation of a quinone can often be achieved by simple addition of an enzyme or stoichiometric amounts of chemoselective oxidant, or by exposure to light. In this Minireview, we discuss the generation and subsequent functionalization of quinones, iminoquinones, and quinone methides. We also discuss practical applications regarding these conjugation strategies.
- Subjects
QUINONE; MOLECULES; NUCLEOPHILIC addition (Chemistry); BACTERIAL conjugation; ENZYMES
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 19, p4749
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201703919