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- Title
Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone.
- Authors
Li, Guohua; Meng, Xianyong; Ren, Zhiguang; Li, Entao; Yan, Feihu; Liu, Jing; Zhang, Ying; Cui, Zhanding; Li, Yuetao; Jin, Hongli; Cao, Zengguo; Yi, Le; Huang, Pei; Chi, Hang; Wang, Hualei; Sun, Weiyang; Wang, Tiecheng; Gao, Yuwei; Zhao, Yongkun; Yang, Songtao
- Abstract
West Nile virus disease (WND) is an arthropod-borne zoonosis responsible for nonspecific fever or severe encephalitis. The pathogen is West Nile virus belonging to the genus Flavivirus, family Flaviviridae. Every year, thousands of cases were reported, which poses significant public health risk. Here, we constructed a West Nile virus chimera, ChiVax-WN01, by replacing the prMΔE gene of JEV SA14-14-2 with that of the West Nile virus NY99. The ChiVax-WN01 chimera showed clear, different characters compared with that of JEV SA14-14-2 and WNV NY99 strain. An animal study indicated that the ChiVax-WN01 chimera presented moderate safety and immunogenicity for 4-week female BALB/c mice.
- Subjects
WEST Nile fever; WEST Nile virus; JAPANESE encephalitis viruses; SPINE; ARBOVIRUS diseases
- Publication
Viruses (1999-4915), 2021, Vol 13, Issue 7, p1262
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v13071262