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- Title
Cyclols Revisited: Facile Synthesis of Medium-Sized Cyclic Peptides.
- Authors
Mendoza‐Sanchez, Rodrigo; Corless, Victoria B.; Nguyen, Q. Nhu N.; Bergeron‐Brlek, Milan; Frost, John; Adachi, Shinya; Tantillo, Dean J.; Yudin, Andrei K.
- Abstract
Medium-sized rings, particularly the corresponding cyclic peptides, are challenging synthetic targets. In the present study, we report an approach to medium-sized cyclic peptides through targeted formation and collapse of cyclol intermediates. This methodology operates on β-amino imides derived from 2,5-diketopiperazines and offers a straightforward transition from frequently examined scaffolds in drug discovery to a rarely visited class of medium-sized rings.
- Subjects
CYCLIC peptides synthesis; DIKETOPIPERAZINES; PROTEIN folding; POLYPEPTIDES; CHROMOPHORES; GREEN fluorescent protein
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 54, p13319
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201703616