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- Title
Endolymph formation in the inner ear of pigeons.
- Authors
Ninoyu, O.; Hommerich, C.; Morgenstern, C.
- Abstract
The endolymphatic space of pigeons was studied by using double-barrelled electrodes with a potassium liquid ion exchanger. The K+ activity of the endolymph was 155 mM in the cochlea and 133 mM in the ampulla, respectively. Positive DC potential in the cochlea (+14.5 mV) was much lower than in guinea pigs (+80 mV) whereas in the ampulla of pigeons the DC potential (+7.4 mV) was 2 times higher than that of guinea pigs (+3.9 mV). General application of ethacrynic acid in pigeons induced a weak change in DC potential and no typical intercellular edema in the cochlea and ampulla. Local application of ethacrynic acid and ouabain in the cochlea and ampulla of pigeons induced a negative DC potential of between -30 and -40 mV. This negative DC potential was higher than the anoxia-induced negative potential. Short hypoxia during a drug-induced DC potential resulted in a decrease in DC potential above the diffusion potential. Below the diffusion potential additional hypoxia increased the DC potential independent of the cause of intoxication.
- Subjects
BIRD physiology; COCHLEA physiology; POTASSIUM metabolism; LABYRINTHINE fluids; PERILYMPH; ENDOLYMPH; ANIMAL experimentation; AUDITORY evoked response; BIRDS; CARDIAC glycosides; COMPARATIVE studies; ETHACRYNIC acid; GUINEA pigs; RESEARCH methodology; MEDICAL cooperation; RESEARCH; EVALUATION research; PHARMACODYNAMICS; PHYSIOLOGY
- Publication
ORL, 1987, Vol 49, Issue 1, p1
- ISSN
0301-1569
- Publication type
journal article
- DOI
10.1159/000275899