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- Title
Animal models have little to teach us about Type 1 diabetes: 1. In support of this proposal.
- Authors
Roep, B. O.; Atkinson, M.
- Abstract
The article presents animal models to teach about Type 1 diabetes. Animal models such as the non-obese diabetic mouse and the bio-breeding rat develop immune-mediated disease with features resembling Type I diabetes in humans. Although these animal models of autoimmune diabetes have proved to be valuable tools to study certain aspects of the disease process, they have also led to misconceptions and erroneous extrapolations, as well as false expectations with regard to the efficacy of immunotherapy.
- Subjects
DIABETES; ANIMAL disease models; ANIMAL models in research; LABORATORY mice; AUTOIMMUNE diseases; IMMUNOTHERAPY
- Publication
Diabetologia, 2004, Vol 47, Issue 10, p1650
- ISSN
0012-186X
- Publication type
Article
- DOI
10.1007/s00125-004-1517-1