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- Title
[ 18 F]fluoride Activation and 18 F-Labelling in Hydrous Conditions—Towards a Microfluidic Synthesis of PET Radiopharmaceuticals.
- Authors
Ovdiichuk, Olga; Lahdenpohja, Salla; Béen, Quentin; Tanguy, Laurent; Kuhnast, Bertrand; Collet-Defossez, Charlotte
- Abstract
18F-labelled radiopharmaceuticals are indispensable in positron emission tomography. The critical step in the preparation of 18F-labelled tracers is the anhydrous F-18 nucleophilic substitution reaction, which involves [18F]F− anions generated in aqueous media by the cyclotron. For this, azeotropic drying by distillation is widely used in standard synthesisers, but microfluidic systems are often not compatible with such a process. To avoid this step, several methods compatible with aqueous media have been developed. We summarised the existing approaches and two of them have been studied in detail. [18F]fluoride elution efficiencies have been investigated under different conditions showing high 18F-recovery. Finally, a large scope of precursors has been assessed for radiochemical conversion, and these hydrous labelling techniques have shown their potential for tracer production using a microfluidic approach, more particularly compatible with iMiDEV™ cassette volumes.
- Subjects
HYDROUS; NUCLEOPHILIC substitution reactions; RADIOPHARMACEUTICALS; POSITRON emission tomography; AZEOTROPIC distillation; FLUORIDE varnishes
- Publication
Molecules, 2024, Vol 29, Issue 1, p147
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29010147