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- Title
Poly(A)-binding proteins: Structure, domain organization, and activity regulation.
- Authors
Eliseeva, I.; Lyabin, D.; Ovchinnikov, L.
- Abstract
RNA-binding proteins are of vital importance for mRNA functioning. Among these, poly(A)-binding proteins (PABPs) are of special interest due to their participation in virtually all mRNA-dependent events that is caused by their high affinity for A-rich mRNA sequences. Apart from mRNAs, PABPs interact with many proteins, thus promoting their involvement in cellular events. In the nucleus, PABPs play a role in polyadenylation, determine the length of the poly(A) tail, and may be involved in mRNA export. In the cytoplasm, they participate in regulation of translation initiation and either protect mRNAs from decay through binding to their poly(A) tails or stimulate this decay by promoting mRNA inter-actions with deadenylase complex proteins. This review presents modern notions of the role of PABPs in mRNA-dependent events; peculiarities of regulation of PABP amount in the cell and activities are also discussed.
- Subjects
POLY(A)-binding protein I; PROTEIN structure; MESSENGER RNA; ADENYLATION (Biochemistry); TRANSLATION initiation factors (Biochemistry)
- Publication
Biochemistry (00062979), 2013, Vol 78, Issue 13, p1377
- ISSN
0006-2979
- Publication type
Article
- DOI
10.1134/S0006297913130014