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- Title
ساخت و مشخصه یابی پوشش زخم نانو فیبری حاوی نانورسهای کونژوگه شده با جنتامایسین.
- Authors
هادی صمدیان; مهناز محمد پور; سهيلا زارع; ژیلا ایزدی; سجاد مرادی; هاشم مرادی; حسین درخشان خواه
- Abstract
Introduction: The development of bioactive wound dressings with high healing efficacy is one of the most important domains in interdisciplinary fields. The objective of the present study was to fabricate and characterize a nanofibrous wound dressing containing gentamicin-conjugated nanoclay. Material & Methods: First, the interaction between the structure of nanoclays and gentamicin was evaluated based on computer simulation methods and using Gaussian software. Then, the purified nanoclays were conjugated with gentamicin, and the properties of the resulting nanoparticles were analyzed. The synthesized nanocomplex was integrated into the nanofiber structure using the electrospinning method, and the nanofiber wound covering was identified. Finally, the biological properties of nanofiber wound dressing were investigated. Results: Numerical studies indicated that there were negatively charged oxygen groups on both sides of the nanoclay plates, which could make stable interactions with the positively charged nitrogen in gentamicin, and the drug was well-loaded between pages. The characterization results demonstrated that nanofiber wound dressings had acceptable characteristics in terms of morphology, diameter, wettability, mechanical properties, swelling, and bacterial penetration barrier. These functions provide a suitable environment for wound healing. The addition of gentamicin led to beneficial biological properties for prepared wound dressings, and these nanofibers had acceptable hemocompatibility and biocompatibility. Discussion & Conclusion: The findings of the present research can be a fundamental step for using the combination of kaolin/polyvinyl alcohol nanofibers containing gentamicin in various fields of pharmaceutical bioengineering, including the production of wound dressings.
- Subjects
WOUND healing; COMPUTER simulation; BANDAGES &; bandaging; ELECTROSPINNING; EDEMA; BIOLOGICAL products; NITROGEN; BIOMEDICAL materials; KAOLIN; POLYSTYRENE; BIOMEDICAL engineering; NANOTECHNOLOGY; GENTAMICIN; MOLECULAR structure; SURGICAL dressings; NANOPARTICLES; PENETRATING wounds
- Publication
Journal of Ilam University of Medical Sciences, 2024, Vol 32, Issue 1, p83
- ISSN
1563-4728
- Publication type
Article