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- Title
Mast cells participate in allograft rejection: can IL-37 play an inhibitory role?
- Authors
Conti, Pio; Caraffa, Alessandro; Ronconi, Gianpaolo; Kritas, Spiros K.; Mastrangelo, Filiberto; Tettamanti, Lucia; Frydas, Ilias; Theoharides, Theoharis C.
- Abstract
Objective: The aim of this study was to evaluate the role of mast cells (MCs) in allograft rejection, eventually inhibited by IL-37. Immune cells including MCs participate in allograft rejection by generating IL-1, IL-33, TNF and other cytokines.Methods: We evaluated allograft rejection on the experience of our experimental data and using the relevant literature. Results: MCs are involved in initiation and regulation of innate and adaptive immune responses-pathways. MCs are important pro-inflammatory cells which express high-affinity receptor FceRI and can be activated by IgE and some pro-inflammatory cytokines, such as IL-1 and IL-33. The cross-linkage of high affinity IgE receptor on MCs by antigen ligation has a crucial role in allergy, asthma, anaphylaxis, cancer and allograft rejection. MCs mediate immunity in organ transplant, leading to the activation of allospecific T cells implicated in the rejection and generate pro-inflammatory cytokines/chemokines. IL-1 pro-inflammatory cytokine family members released by MCs mediate allograft rejection and inflammation. IL-37 is also an IL-1 family member generated by macrophage cell line in small amounts, which binds to IL-18Rα and produces an anti-inflammatory effect. IL-37 provokes the inhibition of TLR signaling, TLR-induced mTOR and (MyD88)-mediated responses, suppressing pro-inflammatory IL-1 family members and increasing IL-10. Conclusion: IL-37 inhibition offers the opportunity to immunologically modulate MCs, by suppressing their production of IL-1 family members and reducing the risk of allograft rejection, resulting as a potential good therapeutic new cytokine. Here, we report the relationship between inflammatory MCs, allograft rejection and pro-inflammatory and anti-inflammatory IL-37.
- Subjects
MAST cells; INTERLEUKIN-37; CYTOKINES; CHEMOKINES; INFLAMMATION; MACROPHAGES; HOMOGRAFTS
- Publication
Inflammation Research, 2018, Vol 67, Issue 9, p747
- ISSN
1023-3830
- Publication type
Article
- DOI
10.1007/s00011-018-1166-3