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- Title
Structure and Function of Archaeal Translation Initiation Factor 2 Fragments Containing Cys2‑Cys2 Motifs.
- Authors
Nikonov, Oleg S.; Nevskaya, Natalia A.; Garber, Maria B.; Nikonov, Stanislav V.
- Abstract
The heterotrimeric (αβγ) translation initiation factor 2 of archaea and eukaryotes (a/eIF2) supplies the P-site of the ribosome with the initiation tRNA. Its two subunits (β and γ) contain the Cys2‑Cys2 motif, which is capable of forming a stable zinc finger structure in the presence of zinc ions. In this work, comparative analysis of the fragments containing Cys2‑Cys2 motifs in the aIF2β and aIF2γ structures from different organisms was carried out and their environments in crystals was analyzed. Based on the obtained data, a conclusion was made that the conformation and role of these fragments in the β- and γ-subunits of the aIF2 are different.
- Subjects
ZINC-finger proteins; PROTHROMBIN; ZINC ions; TRANSFER RNA
- Publication
Biochemistry (00062979), 2021, Vol 86, Issue 8, p1003
- ISSN
0006-2979
- Publication type
Article
- DOI
10.1134/S0006297921080101