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- Title
An Eco-Friendly Antheraea Pernyi Silk Gland Protein/Sodium Alginate Multiple Network Hydrogel as Potential Drug Release Systems.
- Authors
Li, Jia; Wang, Bo-Xiang; Cheng, De-Hong; Zhang, Yue; Yao, Qiang; Ji, Xin-bin; Guo, Jing; Lu, Yan-Hua
- Abstract
To improve the versatility of the sodium alginate-loaded bio-hydrogels, Antheraea pernyi silk gland protein/sodium alginate drug-loaded hydrogels were prepared by using an eco-friendly multiple network cross-link technology. Fourier transform infrared (FT-IR) spectroscopy and UV-Vis spectrophotometer were used separately to evaluate the chemical structure and drug release behavior of drug-loaded hydrogels. The antibacterial drug carrier gels were evaluated by using inhibition zone test against the S. aureus and E. coli. The CCK-8 assay was used to assess the biocompatibility of drug loaded hydrogels. The FT-IR results showed that there was a strong interaction within the drug loaded hydrogels, and the ASGP was beneficial to enhance the interaction within the drug loaded hydrogels. UV-Vis spectrophotometer results indicated the cumulative release reached 80% within 400 min. Antibacterial bio-hydrogels had a good antibacterial property, especially the antibacterial bio-hydrogels with bacitracin exhibits superior to other antibacterial agents. The drug-loaded bio-hydrogels exhibited the adhesion and proliferation of RSC96 cells and perfected biocompatibility. This provides a new idea for further research and development of tissue-friendly drug-loaded biomaterials.
- Subjects
SODIUM alginate; HYDROGELS; DRUG delivery systems; FOURIER transform infrared spectroscopy; CHEMICAL structure
- Publication
Gels (2310-2861), 2023, Vol 9, Issue 1, p4
- ISSN
2310-2861
- Publication type
Article
- DOI
10.3390/gels9010004