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- Title
Karnozin a ß-alanin v seniorském věku: Jejich vliv na kosterní svalstvo a neurodegenerativní onemocnění.
- Authors
Študent, Vladimír; Vostálová, Jitka; Vidlář, Aleš; Jarošová, Alexandra; Šimánek, Vilím
- Abstract
Carnosine (ß-alanyl-L-histidine) is a dipeptide composed of the amino acid ß-alanine and the L-histidine. Carnosine and both amino acids are found in the brain and skeletal muscle of all vertebrates. The physiological function of carnosine in brain tissue is to protect intracellular proteins from damage by oxygen radicals, modification by glycation and formation of cross-links between protein chains. In skeletal muscle, carnosine reduces muscle fatigue caused by increased lactic acid levels and decreased tissue pH. With increasing biological age, carnosine concentration in both brain tissue and white skeletal muscle fibres decreases. There is a loss of muscle mass (sarcopenia) and deterioration of sensory and cognitive functions. These degenerative processes can be delayed by consuming carnosine-rich foods or diet supplemented with pure ß-alanine. This amino acid determines the rate of endogenic carnosine synthesis and thus its concentration in brain and muscle tissues. This article is an overview of the present knowledge on the role of carnosine in the process of aging and the importance of the diet enrichment with ß-alanine or carnosine.
- Publication
Medicina Pro Praxi, 2020, Issue 5, p329
- ISSN
1214-8687
- Publication type
Article