We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dietary heat‐killed Lactobacillus brevis SBC8803 (SBL88™) improves hippocampus‐dependent memory performance and adult hippocampal neurogenesis.
- Authors
Ishikawa, Rie; Fukushima, Hotaka; Nakakita, Yasukazu; Kado, Hisao; Kida, Satoshi
- Abstract
Aims: Lactobacillus species are used widely as various food and supplements to improve health. Previous studies have shown that heat‐killed Lactobacillus brevis SBC8803 induces serotonin release from intestinal cells and affects sleep rhythm and the autonomic nervous system. However, the effect of SBC8803 on cognitive function remains unknown. Here, we examined the effects of dietary heat‐killed SBC8803 on hippocampus‐dependent memory and adult hippocampal neurogenesis. Methods: Hippocampus‐dependent memory performance was assessed in mice fed heat‐killed SBC8803 using social recognition and contextual fear conditioning tasks. Adult hippocampal neurogenesis was evaluated before, during, and after feeding heat‐killed SBC8803 by measuring the number of 5‐bromo‐2‐deoxyuridine (BrdU)‐positive cells following systemic injections of BrdU using immunohistochemistry. Results: Mice fed a heat‐killed SBC8803 diet showed an improvement of hippocampus‐dependent social recognition and contextual fear memories and enhanced adult hippocampal neurogenesis by increasing the survival, but not proliferation, of newborn neurons. Conclusion: Dietary heat‐killed SBC8803 functions as memory and neurogenesis enhancers.
- Subjects
DEVELOPMENTAL neurobiology; LACTOBACILLUS brevis; HIPPOCAMPUS (Brain); AUTONOMIC nervous system; MEMORY; DIETARY supplements; COGNITIVE ability
- Publication
Neuropsychopharmacology Reports, 2019, Vol 39, Issue 2, p140
- ISSN
2574-173X
- Publication type
Article
- DOI
10.1002/npr2.12054