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- Title
氟虫腈/阝-环糊精衍生物/壳聚糖纳米微球的 制备及性能.
- Authors
张红丽; 张仙娜; 赵雅宁; 玄光善
- Abstract
In this study, β-cyclodextrin (β-CD) was modified and fipronil (FP) was used as a model pesticide, the inclusion complex (ICs) of carboxymethyl-β-cyclodextrin (CM-β-CD) and carboxymethyl-hydroxypropyl-β-cyclodextrin (CM-HP-β-CD) was preparedˈthen ICS and chitosan (CS) were interacted with each other to form nanoparticles (NPs) via electrostatic interaction, and the NPS were characterized. At the same time, the solubility of inclusion complex, the storage stability and light stability of nano-microspheres, and the release behavior in vitro were investigated. The results showed that FP formed 1:1 inclusion complexes with CM-β-CD and CM-HP-β-CD, increasing its solubility in water by 102.34 and 76.29 times, respectively. The drug-loaded nano-microspheres have a regular spherical appearance, the particle size distribution is about 200 nm, and the encapsulation efficiency can reach up to 90.42%. After UV irradiation for 48 h, the degradation rate of both nanoparticles was less than 30%, which was significantly lower than that of FP (88.8%). The release profiles showed the NPs provided sustained release of FP, following the Korsmeyer-Peppas model. The NPs also exhibited a higher release rate under alkaline conditions, which could help improve insecticidal efficacy of alkaline insects in the digestive juice.
- Subjects
CYCLODEXTRINS; FIPRONIL; CHITOSAN
- Publication
Chinese Journal of Pesticide Science / Nongyaoxue Xuebao, 2023, Vol 25, Issue 6, p1322
- ISSN
1008-7303
- Publication type
Article
- DOI
10.16801/j.issn.1008-7303.2023.0088