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- Title
Descripción teórica de la detección electroquímica del fármaco pilocarpina, asistida por el compuesto de colorante escuárico con el oxihidróxido de vanadio (III).
- Authors
Tkach, Volodymyr V.; Kushnir, Marta V.; de Oliveira, Sílvio C.; Ivanushko, Yana G.; Sykyrytska, Tetiana B.; Biryuk, Igor G.; Luganska, Olga V.; Kopiika, Vira V.; Domnich, Valerii I.; Yagodynets, Petro I.; Kormosh, Zholt O.; Morozova, Tetiana V.; I. F. Martins, José; Vaz dos Reis, Lucinda
- Abstract
Introduction: pilocarpine is a drug of natural origin, a non-selective agonist of muscarinic receptors, used in the treatment of a wide variety of ophthalmic pathological states. However, its action strongly depends on the dose, which is why it is necessary to develop a fast and accurate method for its detection. Methodology: A mathematical model is developed and analyzed, which describes the performance of the cathode, modified by vanadium oxyhydroxide, immobilized on a squaric dye, in the detection of pilocarpine. Results: a cathodic process is described, in which polycarpine is reduced, with the interruption of the lactone ring, followed by the formation of the diol corresponding to 2-ethyl-3-((N-methyl)imidazolylmethyl)-4-hydroxybutyric acid. Analysis of the model has confirmed its efficiency in electroanalytical processes. On the other hand, oscillatory behavior in electric current can also occur, even if it occurs beyond the detection limit. Conclusions: vanadium oxyhydroxide can serve as an effective modifier for the cathodic electroanalytical detection of pilocarpine.
- Subjects
MUSCARINIC agonists; MUSCARINIC receptors; ELECTRIC currents; PILOCARPINE; DETECTION limit; OPHTHALMIC drugs
- Publication
Revista Colombiana de Ciencias Químico-Farmacéuticas, 2023, Vol 52, Issue 1, p514
- ISSN
0034-7418
- Publication type
Article
- DOI
10.15446/rcciquifa.v52n1.109398