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- Title
Maternal High-Fat Diet Effects on Adaptations to Metabolic Challenges in Male and Female Juvenile Nonhuman Primates.
- Authors
True, Cadence; Dean, Tyler; Takahashi, Diana; Sullivan, Elinor; Kievit, Paul
- Abstract
<bold>Objective: </bold>This study aimed to determine whether maternal high-fat diet (HFD) consumption in nonhuman primates alters the ability of offspring to adapt metabolically to nutrient and caloric challenges.<bold>Methods: </bold>Offspring from Japanese macaque dams fed either a control (CTR) diet or HFD were weaned onto a CTR diet creating two groups: maternal HFD (mHFD, n = 18) and maternal CTR (mCTR) diet (n = 12). Male and female offspring were exposed to a 5-day 30% calorie restriction and to a 35-day HFD challenge (HFDC), at 16 and 24 months of age, respectively. Caloric intake, body weight, and energy expenditure were measured.<bold>Results: </bold>Offspring from both groups showed similar body weight, food intake, and metabolic adaptations to a 5-day calorie restriction. mHFD offspring demonstrated increased food intake and early weight gain in response to a 35-day HFDC; however, group differences in weight dissipated during the challenge. Unlike mCTR animals, the mHFD group had a significant increase in fasting insulin after acute HFD exposure.<bold>Conclusions: </bold>The current findings indicate that offspring exposed to an mHFD show metabolic adaptations to calorie restriction that are largely similar to those of offspring exposed to a mCTR diet but show delayed adaptation upon exposure to an acute HFDC.
- Subjects
HIGH-fat diet; DIETARY supplements; BODY weight; INGESTION; INSULIN
- Publication
Obesity (19307381), 2018, Vol 26, Issue 9, p1430
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22249