We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Influence of the type of indigestible carbohydrate on plasma and urine short-chain fatty acid profiles in healthy human volunteers.
- Authors
Verbeke, K.; Ferchaud-Roucher, V.; Preston, T.; Small, A. C.; Henckaerts, L.; Krempf, M.; Wang, H.; Vonk, R. J.; Priebe, M. G.
- Abstract
Background/Objectives:Health effects of whole grain foods are becoming more evident. In this study, we analysed the short-chain fatty acid profiles in urine and serum derived from the colonic fermentation process of 13C-barley meals, prepared from barley grown under 13CO2 atmosphere.Subjects/Methods:In a crossover study, five volunteers ingested intact barley kernels (high content of non-starch polysaccharides (NSP) and resistant starch (RS)) and barley porridge (high content of NSP only). Using a newly developed stable isotope technology, we monitored 14 and 24 h postprandially 13C-acetate, 13C-propionate and 13C-butyrate in plasma and urine, respectively. The oro-cecal transit time (OCTT) of the meals was measured with the hydrogen breath test.Results:The OCTT was 6 h and did not differ between the two test meals. An increase of 13C-acetate was observed already early after ingestion of the meals (<6 h) and was attributed to early fermentation of the test meal. A rise in plasma 13C-propionate in the fermentation phase could only be detected after the porridge and not after the kernel meal. An increase in 13C-butyrate was only found in the fermentation phase and was higher after the barley kernels. Urine 13C-short-chain fatty acids data were consistent with these observations.Conclusions:The difference in the profiles of 13C-acetate, 13C-propionate and 13C-butyrate indicates that NSP combined with RS results in an altered fermentation profile than dietary fibre alone.
- Subjects
WHOLE grain foods; INDIGESTION; FATTY acids; POLYSACCHARIDES; PREPARED cereals
- Publication
European Journal of Clinical Nutrition, 2010, Vol 64, Issue 7, p678
- ISSN
0954-3007
- Publication type
Article
- DOI
10.1038/ejcn.2010.92