The article offers information on Ilex guayusa which belongs to the family Aquifoliaceae of shrubs and trees. Topics discussed include growth of guayusa in traditional agroforestry systems in pre-Columbian era that support climate change adaptation; use of guayusa in hallucinogenic herbal formulation by indigenous Shuar people in Amazonian Ecuador and Peru; and marketing of guayusa as a beverage tea for energy in the U.S.